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18 F-Fluoroform: a 18F-trifluoromethylating agent for the synthesis of SCF218F-aromatic derivatives

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Abstract

Herein the synthesis of various SCF218F-containing derivatives is reported by a transition metal-free process. By using HCF218F, readily generated from a bench-stable difluoromethyl sulfonium salt, various aromatic disulfides were easily converted into the desired radiolabelled trifluoromethylthiolated compounds in the presence of a base. This protocol allowed the formation of the SCF218F-containing aromatic derivatives in good to excellent radiochemical yields. This process was also extended to the corresponding selenium derivative.

Graphical abstract: 18F-Fluoroform: a 18F-trifluoromethylating agent for the synthesis of SCF218F-aromatic derivatives

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Publication details

The article was received on 06 Apr 2017, accepted on 28 Apr 2017 and first published on 28 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC02652H
Citation: Chem. Commun., 2017, Advance Article
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    18 F-Fluoroform: a 18F-trifluoromethylating agent for the synthesis of SCF218F-aromatic derivatives

    E. Carbonnel, T. Besset, T. Poisson, D. Labar, X. Pannecoucke and P. Jubault, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC02652H

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