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Copper-catalyzed remote (δ) C(sp3)–H bond amination: a practical strategy to construct pyrrolidine derivatives

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Abstract

We report a copper-catalyzed remote C(sp3)–H bond amination reaction that converts acyclic amines to pyrrolidines. This reaction occurs selectively at the carbon δ to the amine functionality. Primary, secondary and tertiary C–H bonds are all suitable for the amination reactions in the presence of an inexpensive and commercially available copper catalyst.

Graphical abstract: Copper-catalyzed remote (δ) C(sp3)–H bond amination: a practical strategy to construct pyrrolidine derivatives

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Publication details

The article was received on 05 Apr 2017, accepted on 04 May 2017 and first published on 04 May 2017


Article type: Communication
DOI: 10.1039/C7CC02624B
Citation: Chem. Commun., 2017, Advance Article
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    Copper-catalyzed remote (δ) C(sp3)–H bond amination: a practical strategy to construct pyrrolidine derivatives

    D. Meng, Y. Tang, J. Wei, X. Shi and M. Yang, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC02624B

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