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Issue 50, 2017
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Coordination strategy-induced selective C–H amination of 8-aminoquinolines

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Abstract

In this study, we broke through the directing function of the amide group. The coordination interaction between metal and directing-group enhanced the reactivity of the substrate. Using this strategy, we realized the selective amination of 8-aminoquinolines at the C5 position via employing azoles as the source of amine. Various kinds of 8-aminoquinolines and different substituted azoles were compatible to afford the corresponding C–N coupling products.

Graphical abstract: Coordination strategy-induced selective C–H amination of 8-aminoquinolines

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Publication details

The article was received on 05 Apr 2017, accepted on 24 May 2017 and first published on 24 May 2017


Article type: Communication
DOI: 10.1039/C7CC02601C
Citation: Chem. Commun., 2017,53, 6736-6739
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    Coordination strategy-induced selective C–H amination of 8-aminoquinolines

    H. Yi, H. Chen, C. Bian, Z. Tang, A. K. Singh, X. Qi, X. Yue, Y. Lan, J. Lee and A. Lei, Chem. Commun., 2017, 53, 6736
    DOI: 10.1039/C7CC02601C

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