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An eco-friendly in situ activatable antibiotic via cucurbit[8]uril-mediated supramolecular crosslinking of branched polyethylenimine

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Abstract

We report an unprecedented, eco-friendly, in situ activatable model antibiotic, phenylalanyl-polyethylenimine (PhePEI), to potentially diminish antibiotic pollution of the environment and associated antibiotic resistance. The inactive PhePEI can be reversibly activated upon supramolecular crosslinking by cucurbit[8]uril, conferring potent antibacterial activity.

Graphical abstract: An eco-friendly in situ activatable antibiotic via cucurbit[8]uril-mediated supramolecular crosslinking of branched polyethylenimine

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Publication details

The article was received on 30 Mar 2017, accepted on 08 May 2017 and first published on 08 May 2017


Article type: Communication
DOI: 10.1039/C7CC02466E
Citation: Chem. Commun., 2017, Advance Article
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    An eco-friendly in situ activatable antibiotic via cucurbit[8]uril-mediated supramolecular crosslinking of branched polyethylenimine

    S. Li, N. Jiang, W. Zhao, Y. Ding, Y. Zheng, L. Wang, J. Zheng and R. Wang, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC02466E

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