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Issue 43, 2017
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Monitoring of nanoparticle reactivity in solution: interaction of L-lysine and Ru nanoparticles probed by chemical shift perturbation parallels regioselective H/D exchange

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Abstract

Thanks to new water-soluble Ru nanoparticles (NPs) stabilized by sulfonated NHC ligands, we demonstrate that it is possible to monitor the catalyst/substrate interaction using NMR chemical shift perturbations (CSPs), under conditions that closely resemble those applied during the enantiospecific C–H deuteration of L-lysine. Correlating the pH dependence of the interaction of L-lysine with the surface of the RuNPs and its subsequent deuteration, our study underscores the importance of oriented binding to the surface as a critical factor for H/D exchange.

Graphical abstract: Monitoring of nanoparticle reactivity in solution: interaction of l-lysine and Ru nanoparticles probed by chemical shift perturbation parallels regioselective H/D exchange

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Publication details

The article was received on 30 Mar 2017, accepted on 08 May 2017 and first published on 08 May 2017


Article type: Communication
DOI: 10.1039/C7CC02445B
Citation: Chem. Commun., 2017,53, 5850-5853
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    Monitoring of nanoparticle reactivity in solution: interaction of L-lysine and Ru nanoparticles probed by chemical shift perturbation parallels regioselective H/D exchange

    L. M. Martínez-Prieto, E. A. Baquero, G. Pieters, J. C. Flores, E. de Jesús, C. Nayral, F. Delpech, P. W. N. M. van Leeuwen, G. Lippens and B. Chaudret, Chem. Commun., 2017, 53, 5850
    DOI: 10.1039/C7CC02445B

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