Jump to main content
Jump to site search


Novel chemical probes for the investigation of nonribosomal peptide assembly

Author affiliations

Abstract

Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.

Graphical abstract: Novel chemical probes for the investigation of nonribosomal peptide assembly

Back to tab navigation

Supplementary files

Publication details

The article was received on 30 Mar 2017, accepted on 12 Jun 2017 and first published on 19 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC02427D
Citation: Chem. Commun., 2017, Advance Article
  •   Request permissions

    Novel chemical probes for the investigation of nonribosomal peptide assembly

    Y. T. C. Ho, D. J. Leng, F. Ghiringhelli, I. Wilkening, D. P. Bushell, O. Köstner, E. Riva, J. Havemann, D. Passarella and M. Tosin, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC02427D

Search articles by author

Spotlight

Advertisements