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Issue 52, 2017
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Novel chemical probes for the investigation of nonribosomal peptide assembly

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Abstract

Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.

Graphical abstract: Novel chemical probes for the investigation of nonribosomal peptide assembly

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Publication details

The article was received on 30 Mar 2017, accepted on 12 Jun 2017 and first published on 19 Jun 2017


Article type: Communication
DOI: 10.1039/C7CC02427D
Citation: Chem. Commun., 2017,53, 7088-7091
  • Open access: Creative Commons BY license
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    Novel chemical probes for the investigation of nonribosomal peptide assembly

    Y. T. C. Ho, D. J. Leng, F. Ghiringhelli, I. Wilkening, D. P. Bushell, O. Köstner, E. Riva, J. Havemann, D. Passarella and M. Tosin, Chem. Commun., 2017, 53, 7088
    DOI: 10.1039/C7CC02427D

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