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Laser Post-Ionisation Combined with a High Resolving Orbitrap Mass Spectrometer for Enhanced MALDI-MS Imaging of Lipids

Abstract

Coupling laser-postionisation with a highly resolving MALDI Orbitrap mass spectrometer has realised an up to ~100-fold increase in sensitivity and enhanced chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI This could constitute a major breakthrough for biomedical research.

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Publication details

The article was received on 27 Mar 2017, accepted on 18 May 2017 and first published on 18 May 2017


Article type: Communication
DOI: 10.1039/C7CC02325A
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Laser Post-Ionisation Combined with a High Resolving Orbitrap Mass Spectrometer for Enhanced MALDI-MS Imaging of Lipids

    S. Ellis, J. Soltwisch, M. R. L. Paine, K. Dreisewerd and R. Heeren, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC02325A

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