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Issue 53, 2017
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Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids

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Abstract

Coupling laser post-ionisation with a high resolving power MALDI Orbitrap mass spectrometer has realised an up to ∼100-fold increase in the sensitivity and enhanced the chemical coverage for MALDI-MS imaging of lipids relative to conventional MALDI. This could constitute a major breakthrough for biomedical research.

Graphical abstract: Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids

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Publication details

The article was received on 27 Mar 2017, accepted on 18 May 2017 and first published on 18 May 2017


Article type: Communication
DOI: 10.1039/C7CC02325A
Citation: Chem. Commun., 2017,53, 7246-7249
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    Laser post-ionisation combined with a high resolving power orbitrap mass spectrometer for enhanced MALDI-MS imaging of lipids

    S. R. Ellis, J. Soltwisch, M. R. L. Paine, K. Dreisewerd and R. M. A. Heeren, Chem. Commun., 2017, 53, 7246
    DOI: 10.1039/C7CC02325A

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