Issue 55, 2017

Pd-catalyzed regioselective intramolecular direct arylation of 3-indolecarboxamides: access to spiro-indoline-3,3′-oxindoles and 5,11-dihydro-6H-indolo[3,2-c]quinolin-6-ones

Abstract

We report regioselective intramolecular direct C-3 and C-2 arylations of the indole rings of N-(o-bromophenyl)-3-indolecarboxamides for diastereospecific production of spiro-indoline-3,3′-oxindoles and 5,11-dihydro-6H-indolo[3,2-c]quinolin-6-ones, respectively, under different reaction conditions and possibly involving two different pathways.

Graphical abstract: Pd-catalyzed regioselective intramolecular direct arylation of 3-indolecarboxamides: access to spiro-indoline-3,3′-oxindoles and 5,11-dihydro-6H-indolo[3,2-c]quinolin-6-ones

Supplementary files

Article information

Article type
Communication
Submitted
25 Mar 2017
Accepted
14 Jun 2017
First published
14 Jun 2017

Chem. Commun., 2017,53, 7796-7799

Pd-catalyzed regioselective intramolecular direct arylation of 3-indolecarboxamides: access to spiro-indoline-3,3′-oxindoles and 5,11-dihydro-6H-indolo[3,2-c]quinolin-6-ones

X. Xu, J. Liu, L. Lu, F. Wang and B. Yin, Chem. Commun., 2017, 53, 7796 DOI: 10.1039/C7CC02256E

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