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Issue 36, 2017
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Identification of Annexin A2 as a target protein for plant alkaloid matrine

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Abstract

Matrine is a plant alkaloid and a major active component in the Chinese medical herb Sophora flavescens. Matrine has shown potent anti-cancer activities but its molecular target(s) and mechanism are still unknown. Using the photo-affinity labeling approach, for the first time, Annexin A2 was identified as a direct-binding target of matrine in cancer cells.

Graphical abstract: Identification of Annexin A2 as a target protein for plant alkaloid matrine

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Publication details

The article was received on 24 Mar 2017, accepted on 07 Apr 2017 and first published on 11 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC02227A
Citation: Chem. Commun., 2017,53, 5020-5023
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    Identification of Annexin A2 as a target protein for plant alkaloid matrine

    D. Wang, Y. Cao, L. Zheng, D. Lv, L. Chen, X. Xing, Z. Zhu, X. Li and Y. Chai, Chem. Commun., 2017, 53, 5020
    DOI: 10.1039/C7CC02227A

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