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Identification of Annexin A2 as a target protein for plant alkaloid matrine

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Abstract

Matrine is a plant alkaloid and a major active component in the Chinese medical herb Sophora flavescens. Matrine has shown potent anti-cancer activities but its molecular target(s) and mechanism are still unknown. Using the photo-affinity labeling approach, for the first time, Annexin A2 was identified as a direct-binding target of matrine in cancer cells.

Graphical abstract: Identification of Annexin A2 as a target protein for plant alkaloid matrine

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Publication details

The article was received on 24 Mar 2017, accepted on 07 Apr 2017 and first published on 11 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC02227A
Citation: Chem. Commun., 2017, Advance Article
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    Identification of Annexin A2 as a target protein for plant alkaloid matrine

    D. Wang, Y. Cao, L. Zheng, D. Lv, L. Chen, X. Xing, Z. Zhu, X. Li and Y. Chai, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC02227A

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