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Catalytic dehydrogenative dual functionalization of ethers: dealkylation–oxidation–bromination accompanied by C–O bond cleavage via aerobic oxidation of bromide

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Abstract

Catalytic dehydrogenative dual functionalization (DDF) of ethers via oxidation, dealkylation, and α-bromination by the aerobic oxidation of bromide was developed to obtain the corresponding α-bromo ketones in high yields. In particular, the reaction of substituted tetrahydrofurans as cyclic ethers provided 3,3-dibromo tetrahydrofuran-2-ols in high yields selectively through the double α-bromination.

Graphical abstract: Catalytic dehydrogenative dual functionalization of ethers: dealkylation–oxidation–bromination accompanied by C–O bond cleavage via aerobic oxidation of bromide

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Publication details

The article was received on 22 Mar 2017, accepted on 01 May 2017 and first published on 03 May 2017


Article type: Communication
DOI: 10.1039/C7CC02166F
Citation: Chem. Commun., 2017, Advance Article
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    Catalytic dehydrogenative dual functionalization of ethers: dealkylation–oxidation–bromination accompanied by C–O bond cleavage via aerobic oxidation of bromide

    K. Moriyama, T. Hamada, Y. Nakamura and H. Togo, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC02166F

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