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Issue 49, 2017
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Palladium-catalyzed benzofuran and indole synthesis by multiple C–H functionalizations

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Abstract

Heterocyclic compounds are commonly found in the core structures of several pharmaceuticals, natural products, and agrochemicals, thus spurring intensive research for conducting their synthesis in a mild and simpler way. Over the years, a host of different strategies has been introduced in an effort to synthesize these heterocyles. In this context, significant attention has been gained by methodologies that ensure both step as well as atom efficiency. Synthesis of heterocyclic moieties via multiple C–H activations was found to fulfill these expectations besides guaranteeing the use of starting materials that are easily procurable. This review is focused on the current development in the field of benzofuran and indole synthesis using multiple C–H functionalization strategies.

Graphical abstract: Palladium-catalyzed benzofuran and indole synthesis by multiple C–H functionalizations

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Publication details

The article was received on 17 Mar 2017, accepted on 15 May 2017 and first published on 15 May 2017


Article type: Feature Article
DOI: 10.1039/C7CC02053H
Citation: Chem. Commun., 2017,53, 6544-6556
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    Palladium-catalyzed benzofuran and indole synthesis by multiple C–H functionalizations

    S. Agasti, A. Dey and D. Maiti, Chem. Commun., 2017, 53, 6544
    DOI: 10.1039/C7CC02053H

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