Issue 49, 2017

Palladium-catalyzed benzofuran and indole synthesis by multiple C–H functionalizations

Abstract

Heterocyclic compounds are commonly found in the core structures of several pharmaceuticals, natural products, and agrochemicals, thus spurring intensive research for conducting their synthesis in a mild and simpler way. Over the years, a host of different strategies has been introduced in an effort to synthesize these heterocyles. In this context, significant attention has been gained by methodologies that ensure both step as well as atom efficiency. Synthesis of heterocyclic moieties via multiple C–H activations was found to fulfill these expectations besides guaranteeing the use of starting materials that are easily procurable. This review is focused on the current development in the field of benzofuran and indole synthesis using multiple C–H functionalization strategies.

Graphical abstract: Palladium-catalyzed benzofuran and indole synthesis by multiple C–H functionalizations

Article information

Article type
Feature Article
Submitted
17 Mar 2017
Accepted
15 May 2017
First published
15 May 2017

Chem. Commun., 2017,53, 6544-6556

Palladium-catalyzed benzofuran and indole synthesis by multiple C–H functionalizations

S. Agasti, A. Dey and D. Maiti, Chem. Commun., 2017, 53, 6544 DOI: 10.1039/C7CC02053H

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