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Issue 45, 2017
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Lanthanoplatins: emissive Eu(III) and Tb(III) complexes staining nucleoli targeted through Pt–DNA crosslinking

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Abstract

Two highly luminescent water-soluble heterometallic LnPt2 complexes, [{cis-PtCl(NH3)2}2Ln(L)(H2O)](NO3)2 (Ln = Eu (1), Tb (2)), have been designed for their selective nucleoli staining through formation of Pt–DNA crosslinks. The complexes showed significant cellular uptake and distinctive nucleoli localization through intrinsic emission from EuIII or TbIII observed through confocal fluorescence microscopy.

Graphical abstract: Lanthanoplatins: emissive Eu(iii) and Tb(iii) complexes staining nucleoli targeted through Pt–DNA crosslinking

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Publication details

The article was received on 17 Mar 2017, accepted on 12 May 2017 and first published on 12 May 2017


Article type: Communication
DOI: 10.1039/C7CC02047C
Citation: Chem. Commun., 2017,53, 6144-6147
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    Lanthanoplatins: emissive Eu(III) and Tb(III) complexes staining nucleoli targeted through Pt–DNA crosslinking

    K. Singh, S. Singh, P. Srivastava, S. Sivakumar and A. K. Patra, Chem. Commun., 2017, 53, 6144
    DOI: 10.1039/C7CC02047C

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