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Efficient phosphine-mediated formal C(sp3)–C(sp3) coupling reactions of alkyl halides in batch and flow

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Abstract

The construction of C(sp3)–C(sp3) bond is an essential chemical transformation in synthetic chemistry due to its abundance in organic scaffolds. Here we demonstrate a valuable adaptation of the Wittig-type chemical procedure to efficiently facilitate C(sp3)–C(sp3) bond formation utilizing a range of alkyl building blocks. Additionally the method is amenable with flow synthesis to afford coupled products in good to excellent yields without laborious purification process.

Graphical abstract: Efficient phosphine-mediated formal C(sp3)–C(sp3) coupling reactions of alkyl halides in batch and flow

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Publication details

The article was received on 17 Mar 2017, accepted on 11 Apr 2017 and first published on 11 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC02033C
Citation: Chem. Commun., 2017, Advance Article
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    Efficient phosphine-mediated formal C(sp3)–C(sp3) coupling reactions of alkyl halides in batch and flow

    U. P. N. Tran, K. J. Hock, C. P. Gordon, R. M. Koenigs and T. V. Nguyen, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC02033C

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