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Digitally encoded silica microparticles for multiplexed nucleic acid detection

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Abstract

A robust high throughput suspension array was proposed to analyze biomolecules. To exploit its capacity for nucleic acid detection, we designed a multiplex nested asymmetric PCR (MNAS PCR) that can produce single stranded DNA (ssDNA) efficiently without complicated optimization. Multiplexed HPV genotyping was demonstrated with high selectivity, high sensitivity and rapid hybridization within 20 minutes.

Graphical abstract: Digitally encoded silica microparticles for multiplexed nucleic acid detection

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Publication details

The article was received on 15 Mar 2017, accepted on 08 May 2017 and first published on 16 May 2017


Article type: Communication
DOI: 10.1039/C7CC01974B
Citation: Chem. Commun., 2017, Advance Article
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    Digitally encoded silica microparticles for multiplexed nucleic acid detection

    W. Xu, C. Chen, X. Ma, L. Yuan, S. Liu, K. Zheng and J. Li, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC01974B

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