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Issue 60, 2017
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Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters

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Abstract

Rapidly growing cancer cells have increased levels of intracellular polyamines compared to normal, healthy tissues. Based on the selective reactivity of glycine propargyl esters, probes were synthesized that show evidence for selective polyamine reactivity, which was then applied for selective cancer cell imaging studies.

Graphical abstract: Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters

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Publication details

The article was received on 14 Mar 2017, accepted on 26 May 2017 and first published on 31 May 2017


Article type: Communication
DOI: 10.1039/C7CC01934C
Citation: Chem. Commun., 2017,53, 8403-8406
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    Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters

    K. K. H. Vong, K. Tsubokura, Y. Nakao, T. Tanei, S. Noguchi, S. Kitazume, N. Taniguchi and K. Tanaka, Chem. Commun., 2017, 53, 8403
    DOI: 10.1039/C7CC01934C

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