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Issue 48, 2017
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Highly nucleophilic vitamin B12-assisted nickel-catalysed reductive coupling of aryl halides and non-activated alkyl tosylates

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Abstract

Reductive cross-coupling of aryl halides with ubiquitous alkyl tosylates was developed using a combination of nickel and vitamin B12 (VB12: cyanocobalamin) catalysts. The tosylate was activated by reduced VB12 to form alkyl cobalt(III), which served as a good alkylating agent for aryl-nickel species, leading to C(sp3)–C(sp2) bond formation.

Graphical abstract: Highly nucleophilic vitamin B12-assisted nickel-catalysed reductive coupling of aryl halides and non-activated alkyl tosylates

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Publication details

The article was received on 15 Mar 2017, accepted on 19 Apr 2017 and first published on 19 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01932G
Citation: Chem. Commun., 2017,53, 6401-6404
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    Highly nucleophilic vitamin B12-assisted nickel-catalysed reductive coupling of aryl halides and non-activated alkyl tosylates

    K. Komeyama, R. Ohata, S. Kiguchi and I. Osaka, Chem. Commun., 2017, 53, 6401
    DOI: 10.1039/C7CC01932G

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