Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.



Highly nucleophilic vitamin B12-assisted nickel-catalysed reductive coupling of aryl halides and non-activated alkyl tosylates

Author affiliations

Abstract

Reductive cross-coupling of aryl halides with ubiquitous alkyl tosylates was developed using a combination of nickel and vitamin B12 (VB12: cyanocobalamin) catalysts. The tosylate was activated by reduced VB12 to form alkyl cobalt(III), which served as a good alkylating agent for aryl-nickel species, leading to C(sp3)–C(sp2) bond formation.

Graphical abstract: Highly nucleophilic vitamin B12-assisted nickel-catalysed reductive coupling of aryl halides and non-activated alkyl tosylates

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 15 Mar 2017, accepted on 19 Apr 2017 and first published on 19 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01932G
Citation: Chem. Commun., 2017, Advance Article
  •   Request permissions

    Highly nucleophilic vitamin B12-assisted nickel-catalysed reductive coupling of aryl halides and non-activated alkyl tosylates

    K. Komeyama, R. Ohata, S. Kiguchi and I. Osaka, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC01932G

Search articles by author