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Issue 34, 2017
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Chemo-enzymatic synthesis of equisetin

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We here report that the biosynthesis of equisetin, a fungal tetramate natural product with potent anti-infectious activity, relies on Fsa2, a Diels–Alderase that constructs the trans-decalin system of the molecule in a stereo-selective manner. This finding led to the development of a concise chemo-enzymatic route toward the synthesis of equisetin, which involves facile preparation of a linear polyene precursor via 7-steps and Fsa2 activity for equisetin maturation through an intramolecular Diels–Alder reaction, thus exemplifying the significance of the combination of chemical and biological methods to achieve structurally complex cyclic natural products and their derivatives.

Graphical abstract: Chemo-enzymatic synthesis of equisetin

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The article was received on 14 Mar 2017, accepted on 01 Apr 2017 and first published on 04 Apr 2017

Article type: Communication
DOI: 10.1039/C7CC01929G
Citation: Chem. Commun., 2017,53, 4695-4697
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    Chemo-enzymatic synthesis of equisetin

    X. Li, Q. Zheng, J. Yin, W. Liu and S. Gao, Chem. Commun., 2017, 53, 4695
    DOI: 10.1039/C7CC01929G

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