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An aza-BODIPY based near-infrared fluorescent probe for sensitive discrimination of cysteine/homocysteine and glutathione in living cells

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Abstract

Discriminative detection of glutathione (GSH) from cysteine/homocysteine (Cys/Hcy) is achieved through two emission channel analysis using a stable, highly sensitive, and selective near-infrared fluorescent probe that bears 7-nitrobenzo-2-oxa-1,3-diazole and aza-BODIPY units. The probe was successfully applied for simultaneous determination of GSH and Cys/Hcy in living cells.

Graphical abstract: An aza-BODIPY based near-infrared fluorescent probe for sensitive discrimination of cysteine/homocysteine and glutathione in living cells

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Publication details

The article was received on 09 Mar 2017, accepted on 11 Apr 2017 and first published on 18 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01814B
Citation: Chem. Commun., 2017, Advance Article
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    An aza-BODIPY based near-infrared fluorescent probe for sensitive discrimination of cysteine/homocysteine and glutathione in living cells

    H. Xiang, H. P. Tham, M. D. Nguyen, S. Z. Fiona Phua, W. Q. Lim, J. Liu and Y. Zhao, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC01814B

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