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Issue 28, 2017
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Development of an enantioselective amine–silver co-catalyzed Conia-ene reaction

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Abstract

The development of a novel cooperative catalytic system for an amine–silver co-catalyzed Conia-ene reaction of alkyne-tethered C–H-acidic compounds is reported. By using a cost-effective silver salt and a small diamine for the 5-exo-dig-cyclization the cyclopentane products are obtained in very good yields. The enantioselectivity of the reaction could be controlled by exchanging the diamine co-catalyst with a cinchona-derived primary amine.

Graphical abstract: Development of an enantioselective amine–silver co-catalyzed Conia-ene reaction

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Publication details

The article was received on 09 Mar 2017, accepted on 16 Mar 2017 and first published on 17 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC01807J
Citation: Chem. Commun., 2017,53, 3956-3959
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    Development of an enantioselective amine–silver co-catalyzed Conia-ene reaction

    M. Blümel, D. Hack, L. Ronkartz, C. Vermeeren and D. Enders, Chem. Commun., 2017, 53, 3956
    DOI: 10.1039/C7CC01807J

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