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Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting

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Abstract

The first NIR KIAA1363-targeting probe, NB-AX, specifically and instantly featured an “off–on” switch upon gradual addition of KIAA1363 over all kinds of other biomolecules, and its detection limit was initially calculated to be 0.58 μg mL−1 (3δ/k). The probe was also able to be used in ultrafast distinguishing of breast cancer cells from normal cells in fluorescence imaging and applied in tissue imaging and tumor imaging in vivo.

Graphical abstract: Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting

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Publication details

The article was received on 09 Mar 2017, accepted on 05 Apr 2017 and first published on 05 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01798G
Citation: Chem. Commun., 2017, Advance Article
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    Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting

    J. Fan, S. Guo, S. Wang, Y. Kang, Q. Yao, J. Wang, X. Gao, H. Wang, J. Du and X. Peng, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC01798G

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