A highly efficient Cu catalyst system for the radical reactions of α-bromocarbonyls
In this communication, we established highly efficient Cu-catalyzed ARGET-ATRS (atom-transfer radical substitution) of alpha-bromocarbonyls with styrenes to produce tert-alkylated styrenes. The maximum TON was up to 12000. Hünig's base was very important to regenerate active CuI. Moreover, a Cu-catalyzed C–C cleavage reaction via SH2′ and intermolecular C–H cyclization of α-bromoimide was found.