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Asymmetric vinylogous Mukaiyama-Michael reaction of α,β-unsaturated 2-acyl imidazoles catalyzed by chiral Sc(III)- or Er(III)-pybox complexes

Abstract

A highly diastereo- and enantioselective vinylogous Mukaiyama-Michael reaction of silyloxyfurans to α,β-unsaturated 2-acyl imidazoles catalyzed by either chiral Sc(III) or Er(III) complex of a pybox ligand has been reported. The enantioenriched γ-butenolides formed in the reaction were further transformed into highly functionalized γ-lactones found as important structural frameworks in a wide range of biologically active natural products

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Publication details

The article was received on 08 Mar 2017, accepted on 13 Apr 2017 and first published on 13 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01763D
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Asymmetric vinylogous Mukaiyama-Michael reaction of α,β-unsaturated 2-acyl imidazoles catalyzed by chiral Sc(III)- or Er(III)-pybox complexes

    S. Rout, A. Das and V. Singh, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC01763D

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