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Issue 31, 2017
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Pd/Cu-catalyzed dual C–H bond carbonylation towards the synthesis of fluorazones

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Abstract

Pd/Cu catalyzed oxidative dual C–H bond activation/carbonylation still remains a great challenge due to the generation of by-products via C–C bond formation. Herein we developed a straightforward Pd/Cu-catalyzed oxidative dual C–H bond carbonylation process to access biologically and pharmaceutically important fluorazones from easily available N-aryl pyrroles and CO. A wide range of functional groups were well tolerated in this transformation, and O2 could be utilized as the only terminal oxidant to promote the oxidative carbonylation process.

Graphical abstract: Pd/Cu-catalyzed dual C–H bond carbonylation towards the synthesis of fluorazones

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Publication details

The article was received on 06 Mar 2017, accepted on 24 Mar 2017 and first published on 24 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC01707C
Citation: Chem. Commun., 2017,53, 4354-4357
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    Pd/Cu-catalyzed dual C–H bond carbonylation towards the synthesis of fluorazones

    F. Liao, R. Shi, Y. Sha, J. Xia, W. Liao and A. Lei, Chem. Commun., 2017, 53, 4354
    DOI: 10.1039/C7CC01707C

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