Jump to main content
Jump to site search

Issue 49, 2017
Previous Article Next Article

Specific dsDNA recognition by a mimic of the DNA binding domain of the c-Myc/Max transcription factor

Author affiliations

Abstract

We here report on the synthesis of the first mimic of the DNA binding domain of the c-Myc/Max-bHLH-ZIP transcription factor able to selectively recognize its cognate E-box sequence 5′-CACGTG-3′ through the major groove of the double-stranded DNA. The designed peptidosteroid conjugate was shown to be effective as DNA binder in the presence of excess competitor DNA.

Graphical abstract: Specific dsDNA recognition by a mimic of the DNA binding domain of the c-Myc/Max transcription factor

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Mar 2017, accepted on 12 May 2017 and first published on 19 May 2017


Article type: Communication
DOI: 10.1039/C7CC01705G
Citation: Chem. Commun., 2017,53, 6653-6656
  •   Request permissions

    Specific dsDNA recognition by a mimic of the DNA binding domain of the c-Myc/Max transcription factor

    Y. Ruiz García, Y. V. Pabon-Martinez, C. I. E. Smith and A. Madder, Chem. Commun., 2017, 53, 6653
    DOI: 10.1039/C7CC01705G

Search articles by author

Spotlight

Advertisements