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Specific dsDNA Recognition by a mimic of the DNA binding domain of the c-Myc/Max transcription factor

Abstract

We here report on the synthesis of the first mimic of the DNA binding domain of the c-Myc/Max-bHLH-ZIP transcription factor able to selectively recognize its cognate E-box sequence 5’-CACGTG-3’ through the major groove of the double-stranded DNA. The designed peptidosteroid conjugate was shown to be effective as DNA binder in the presence of excess competitor DNA.

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Publication details

The article was received on 09 Mar 2017, accepted on 12 May 2017 and first published on 19 May 2017


Article type: Communication
DOI: 10.1039/C7CC01705G
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Specific dsDNA Recognition by a mimic of the DNA binding domain of the c-Myc/Max transcription factor

    Y. Ruiz García, V. Pabon, C. I. E. Smith and A. Madder, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC01705G

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