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Silver-mediated radical 5-exo-dig cyclization of 2-alkynylbenzonitriles: synthesis of phosphinylated 1-indenones

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Abstract

A new silver-mediated 5-exo-dig cyclization of 2-alkynylbenzonitriles with disubstituted phosphine oxide and H2O has been developed. The reaction enables multiple bond-forming events including C–P, C–C and C–O bonds under atmospheric conditions, leading to the concise and direct formation of 28 examples of phosphorus-containing 1-indenones with generally good yields.

Graphical abstract: Silver-mediated radical 5-exo-dig cyclization of 2-alkynylbenzonitriles: synthesis of phosphinylated 1-indenones

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Publication details

The article was received on 03 Mar 2017, accepted on 15 May 2017 and first published on 19 May 2017


Article type: Communication
DOI: 10.1039/C7CC01666B
Citation: Chem. Commun., 2017, Advance Article
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    Silver-mediated radical 5-exo-dig cyclization of 2-alkynylbenzonitriles: synthesis of phosphinylated 1-indenones

    X. Zhu, Q. Zhao, F. Liu, A. Wang, P. Cai, W. Hao, S. Tu and B. Jiang, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC01666B

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