Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 35, 2017
Previous Article Next Article

Light up detection of heparin based on aggregation-induced emission and synergistic counter ion displacement

Author affiliations

Abstract

Heparin is a widely used anticoagulant and the quantification of heparin concentration is pivotal for clinical use. However, previous fluorescent probes for heparin detection are usually based on fluorophores with aggregation-caused quenching (ACQ) properties, which severely restrict their applications for quantitative measurement of heparin in a wide range. Herein, we develop an aggregation-induced emission (AIE) probe HPQ-TBP-I for light up detection of heparin based on the electrostatic interaction-triggered formation of the HPQ-TBP/heparin complex and simultaneous displacement of the fluorescence quencher iodide ion. A linear relationship from 0 to 14 μM of heparin accompanied with a low detection limit of 22 nM was achieved, which fully covers the whole clinical dose range (1.7–10 μM). It is anticipated that this easily accessible and sensitive AIE probe is promising for clinical applications.

Graphical abstract: Light up detection of heparin based on aggregation-induced emission and synergistic counter ion displacement

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 01 Mar 2017, accepted on 06 Apr 2017 and first published on 06 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01602F
Citation: Chem. Commun., 2017,53, 4795-4798
  •   Request permissions

    Light up detection of heparin based on aggregation-induced emission and synergistic counter ion displacement

    S. Li, M. Gao, S. Wang, R. Hu, Z. Zhao, A. Qin and B. Z. Tang, Chem. Commun., 2017, 53, 4795
    DOI: 10.1039/C7CC01602F

Search articles by author