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A universal split spinach aptamer (USSA) for nucleic acid analysis and DNA computation

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Abstract

We demonstrate how a single universal spinach aptamer (USSA) probe can be used to detect multiple (potentially any) nucleic acid sequences. USSA can be used for cost-efficient and highly selective analysis of even folded DNA and RNA analytes, as well as for the readout of outputs of DNA logic circuits.

Graphical abstract: A universal split spinach aptamer (USSA) for nucleic acid analysis and DNA computation

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Publication details

The article was received on 27 Feb 2017, accepted on 10 Apr 2017 and first published on 10 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01540B
Citation: Chem. Commun., 2017, Advance Article
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    A universal split spinach aptamer (USSA) for nucleic acid analysis and DNA computation

    N. Kikuchi and D. M. Kolpashchikov, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC01540B

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