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Cyclic ether synthesis from diols using trimethyl phosphate

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Abstract

Cyclic ethers have been effectively synthesized via the intramolecular cyclization of diols using trimethyl phosphate and NaH. The present cyclization could proceed at room temperature to produce 5–7 membered cyclic ethers in good to excellent yields. Substrates possessing a chiral secondary hydroxy group were transformed into the corresponding chiral cyclic ethers along with the retention of their stereochemistries.

Graphical abstract: Cyclic ether synthesis from diols using trimethyl phosphate

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Publication details

The article was received on 27 Feb 2017, accepted on 05 Apr 2017 and first published on 06 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01514C
Citation: Chem. Commun., 2017, Advance Article
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    Cyclic ether synthesis from diols using trimethyl phosphate

    S. Asai, M. Kato, Y. Monguchi, H. Sajiki and Y. Sawama, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC01514C

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