Issue 29, 2017

Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex

Abstract

An addressable single cell imaging strategy combining ToF-SIMS and confocal fluorescence microscopy imaging has been developed, and sucessfully applied to visualize the subcellular distribution of an organoruthenium anticancer complex, [(η6-benzene)Ru(N,N-L)Cl]+ (1; L: 4-anilinoquinazoline ligand), showing its accumulation in both cell membrane and nuclei, and verifying its dual-targeting feature.

Graphical abstract: Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex

Supplementary files

Article information

Article type
Communication
Submitted
25 Feb 2017
Accepted
22 Mar 2017
First published
22 Mar 2017

Chem. Commun., 2017,53, 4136-4139

Correlated mass spectrometry and confocal microscopy imaging verifies the dual-targeting action of an organoruthenium anticancer complex

S. Liu, W. Zheng, K. Wu, Y. Lin, F. Jia, Y. Zhang, Z. Wang, Q. Luo, Y. Zhao and F. Wang, Chem. Commun., 2017, 53, 4136 DOI: 10.1039/C7CC01503H

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