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Issue 26, 2017
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Illuminating cytochrome P450 binding: Ru(II)-caged inhibitors of CYP17A1

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Abstract

New Ru(II)-caged abiraterone complexes were synthesized that exhibit strong absorption in the visible region and release the steroidal CYP17A1 inhibitor abiraterone upon exposure to low energy visible light in buffer and prostate cancer cells. Photoinduced release results in abiraterone binding to its CYP17A1 target in an inhibitory mode.

Graphical abstract: Illuminating cytochrome P450 binding: Ru(ii)-caged inhibitors of CYP17A1

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Publication details

The article was received on 23 Feb 2017, accepted on 07 Mar 2017, published on 07 Mar 2017 and first published online on 07 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC01459G
Citation: Chem. Commun., 2017,53, 3673-3676
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    Illuminating cytochrome P450 binding: Ru(II)-caged inhibitors of CYP17A1

    A. Li, R. Yadav, J. K. White, M. K. Herroon, B. P. Callahan, I. Podgorski, C. Turro, E. E. Scott and J. J. Kodanko, Chem. Commun., 2017, 53, 3673
    DOI: 10.1039/C7CC01459G

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