Jump to main content
Jump to site search

Issue 24, 2017
Previous Article Next Article

Silver-promoted (radio)fluorination of unsaturated carbamates via a radical process

Author affiliations

Abstract

The intramolecular fluorocyclization of unsaturated carbamates is described here using a hypervalent iodine reagent in the presence of a silver catalyst. Both (hetero)aryl-substituted olefins and acrylamides can be utilized as effective substrates. Preliminary mechanistic investigations suggest that the reaction proceeds via a cyclization/1,2-(hetero)aryl migration/fluorination cascade involving an unusual radical process. Furthermore, starting from no-carrier-added [18F]TBAF, a simple one-pot, two-step cascade method was developed for the generation of 18F-labeled heterocycles with high radiochemical purity.

Graphical abstract: Silver-promoted (radio)fluorination of unsaturated carbamates via a radical process

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 Feb 2017, accepted on 06 Mar 2017 and first published on 06 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC01393K
Citation: Chem. Commun., 2017,53, 3497-3500
  •   Request permissions

    Silver-promoted (radio)fluorination of unsaturated carbamates via a radical process

    B. Yang, K. Chansaenpak, H. Wu, L. Zhu, M. Wang, Z. Li and H. Lu, Chem. Commun., 2017, 53, 3497
    DOI: 10.1039/C7CC01393K

Search articles by author

Spotlight

Advertisements