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Issue 37, 2017
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Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex

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Abstract

Proteins typically carry out their biological functions as multi-protein complexes, which can significantly affect the affinity of small-molecule inhibitors. HSP70 is an important target in oncology, so to study its chemical biology and the drug discovery potential of the HSP70/BAG1 complex, we designed a high-affinity non-nucleotide fluorescence polarisation probe.

Graphical abstract: Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex

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Publication details

The article was received on 21 Feb 2017, accepted on 14 Apr 2017 and first published on 21 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01376K
Citation: Chem. Commun., 2017,53, 5167-5170
  • Open access: Creative Commons BY license
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    Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex

    L. E. Evans, K. Jones and M. D. Cheeseman, Chem. Commun., 2017, 53, 5167
    DOI: 10.1039/C7CC01376K

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