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Issue 26, 2017
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Novel hypoxia-targeting Pt(IV) prodrugs

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Abstract

Novel Pt(IV) prodrugs targeting hypoxia inducible factor HIF-1α were prepared for evaluating their antitumor activity on hypoxic cancer cells for the first time. The resulting Pt(IV) prodrug exhibited effective inhibition on tumor growth in the HCT-116 xenograft mouse model with low toxicity in vivo.

Graphical abstract: Novel hypoxia-targeting Pt(iv) prodrugs

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Publication details

The article was received on 19 Feb 2017, accepted on 08 Mar 2017 and first published on 08 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC01320E
Citation: Chem. Commun., 2017,53, 3749-3752
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    Novel hypoxia-targeting Pt(IV) prodrugs

    Z. Xu, J. Zhao, S. Gou and G. Xu, Chem. Commun., 2017, 53, 3749
    DOI: 10.1039/C7CC01320E

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