Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.



Transition metal-free C(sp3)–H bond coupling among three methyl groups

Author affiliations

Abstract

A coupling of multiple C(sp3)–H bonds of the methyl group in methyl ketones with dimethyl sulfoxide is developed. This coupling allows the direct C(sp3)–H bond coupling among three methyl groups and affords one C–C bond and one C[double bond, length as m-dash]C bond under transition metal-free conditions. The value-added cyclized 3-methylthiomethyl chroman-4-ones can be synthesized through this method. A plausible mechanism is proposed.

Graphical abstract: Transition metal-free C(sp3)–H bond coupling among three methyl groups

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 18 Feb 2017, accepted on 18 Apr 2017 and first published on 19 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01309D
Citation: Chem. Commun., 2017, Advance Article
  •   Request permissions

    Transition metal-free C(sp3)–H bond coupling among three methyl groups

    Y. Liu, X. Zhan, P. Ji, J. Xu, Q. Liu, W. Luo, T. Chen and C. Guo, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC01309D

Search articles by author