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A chiral cobalt(II) complex catalyzed asymmetric formal [3+2] cycloaddition for the synthesis of 1,2,4-triazolines

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Abstract

A highly efficient catalytic asymmetric formal [3+2] cycloaddition reaction of 5-alkoxyoxazoles with azodicarboxylate compounds has been realized by a chiral N,N′-dioxide/Co(BF4)2·6H2O complex. A series of poly-substituted 1,2,4-triazolines compounds were obtained in moderate to excellent yields (70–99%) with excellent enantioselectivities (82–98% ee).

Graphical abstract: A chiral cobalt(ii) complex catalyzed asymmetric formal [3+2] cycloaddition for the synthesis of 1,2,4-triazolines

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Publication details

The article was received on 17 Feb 2017, accepted on 14 Mar 2017, published on 15 Mar 2017 and first published online on 15 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC01278K
Citation: Chem. Commun., 2017, Advance Article
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    A chiral cobalt(II) complex catalyzed asymmetric formal [3+2] cycloaddition for the synthesis of 1,2,4-triazolines

    B. Ma, W. Luo, L. Lin, X. Liu and X. Feng, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC01278K

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