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Issue 38, 2017
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α,β-Functionalization of saturated ketones with anthranils via Cu-catalyzed sequential dehydrogenation/aza-Michael addition/annulation cascade reactions in one-pot

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Abstract

An efficient method to access functionalized quinolines from the readily available saturated ketones and anthranils has been explored. This one-pot cascade reaction involves the in situ generation of α,β-unsaturated ketones by the copper catalysed dehydrogenation of saturated ketones followed by the aza-Michael addition of anthranils and subsequent annulation.

Graphical abstract: α,β-Functionalization of saturated ketones with anthranils via Cu-catalyzed sequential dehydrogenation/aza-Michael addition/annulation cascade reactions in one-pot

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Publication details

The article was received on 14 Feb 2017, accepted on 13 Apr 2017 and first published on 19 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01195D
Citation: Chem. Commun., 2017,53, 5302-5305
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    α,β-Functionalization of saturated ketones with anthranils via Cu-catalyzed sequential dehydrogenation/aza-Michael addition/annulation cascade reactions in one-pot

    D. K. Tiwari, M. Phanindrudu, S. B. Wakade, J. B. Nanubolu and D. K. Tiwari, Chem. Commun., 2017, 53, 5302
    DOI: 10.1039/C7CC01195D

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