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Integrating optical tweezers with up-converting luminescence: a non-amplification analytical platform for quantitative detection of microRNA-21 sequences

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Abstract

We report a single-microsphere based imaging assay method by integrating up-converting luminescence with optical tweezers for detecting microRNA-21 sequences. This method achieves a competitive detection limit of 12 fM with good selectivity and no dedicated signal amplification designs.

Graphical abstract: Integrating optical tweezers with up-converting luminescence: a non-amplification analytical platform for quantitative detection of microRNA-21 sequences

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Publication details

The article was received on 13 Feb 2017, accepted on 14 Mar 2017, published on 14 Mar 2017 and first published online on 14 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC01133D
Citation: Chem. Commun., 2017, Advance Article
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    Integrating optical tweezers with up-converting luminescence: a non-amplification analytical platform for quantitative detection of microRNA-21 sequences

    C. Li, D. Cao, C. Song, C. Xu, X. Ma, Z. Zhang, D. Pang and H. Tang, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC01133D

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