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Issue 40, 2017
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Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides

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Abstract

We report self-assembled nanocentipedes as multivalent vehicles for the delivery of immunostimulatory CpG ODNs. The multivalent vehicles could be internalized by RAW264.7 cells and stimulate the secretion of large amounts of cytokines, successively inducing effective apoptosis of cancer cells.

Graphical abstract: Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides

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Publication details

The article was received on 13 Feb 2017, accepted on 18 Apr 2017 and first published on 18 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC01128H
Citation: Chem. Commun., 2017,53, 5565-5568
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    Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides

    W. Li, L. Luo, J. Huang, Q. Wang, J. Liu, X. Xiao, H. Fang, X. Yang and K. Wang, Chem. Commun., 2017, 53, 5565
    DOI: 10.1039/C7CC01128H

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