Ru(ii)-Pheox-catalyzed Si–H insertion reaction: construction of enantioenriched carbon and silicon centers

Abstract

We established a highly enantioselective Si–H insertion reaction to construct chiral centers at the carbon and silicon atoms, using a Ru(II)-pheox catalyst. The catalytic asymmetric Si–H insertion reaction of α-methyl-α-diazoesters proceeded smoothly with excellent stereoinduction at both the neighboring carbon and silicon atoms (up to 99% yield and 99% ee).