Jump to main content
Jump to site search

Issue 24, 2017
Previous Article Next Article

A modular platform to develop peptoid-based selective fluorescent metal sensors

Author affiliations

Abstract

Despite the reduction in industrial use of toxic heavy metals, there remain contaminated natural water sources across the world. Herein we present a modular platform for developing selective sensors for toxic metal ions using N-substituted glycine, or peptoid, oligomers coupled to a fluorophore. As a preliminary evaluation of this strategy, structures based on previously identified metal-binding peptoids were synthesized with terminal pyrene moieties. Both derivatives of this initial design demonstrated a turn-off response in the presence of various metal ions. A colorimetric screen was designed to identify a peptoid ligand that chelates Hg(II). Multiple ligands were identified that were able to deplete Hg(II) from a solution selectively in the presence of an excess of competing ions. The C-terminal fluoropeptoid derivatives demonstrated similar selectivity to their label-free counterparts. This strategy could be applied to develop sensors for many different metal ions of interest using a variety of fluorophores, leading to a panel of sensors for identifying various water source contaminants.

Graphical abstract: A modular platform to develop peptoid-based selective fluorescent metal sensors

Back to tab navigation

Supplementary files

Publication details

The article was received on 10 Nov 2016, accepted on 10 Feb 2017 and first published on 08 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00931C
Citation: Chem. Commun., 2017,53, 3477-3480
  •   Request permissions

    A modular platform to develop peptoid-based selective fluorescent metal sensors

    A. S. Knight, R. U. Kulkarni, E. Y. Zhou, J. M. Franke, E. W. Miller and M. B. Francis, Chem. Commun., 2017, 53, 3477
    DOI: 10.1039/C7CC00931C

Search articles by author

Spotlight

Advertisements