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Issue 28, 2017
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Reversible crystal-to-crystal chiral resolution: making/breaking non-bonding S⋯O interactions

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Abstract

An achiral organic molecule adopts a chiral conformation, crystallizing in two morphologies: a racemic form, stable <70 °C, and a homochiral form, stable ≥70 °C. Upon seeding, crystal-to-crystal phase transitions occur reversibly between the racemic and chiral forms. Liquid-to-solid chiral crystallization is observed >90% of the time from the melt.

Graphical abstract: Reversible crystal-to-crystal chiral resolution: making/breaking non-bonding S⋯O interactions

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Publication details

The article was received on 03 Feb 2017, accepted on 13 Mar 2017 and first published on 13 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00907K
Citation: Chem. Commun., 2017,53, 3964-3966
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    Reversible crystal-to-crystal chiral resolution: making/breaking non-bonding S⋯O interactions

    R. A. Mayo, D. J. Sullivan, T. A. P. Fillion, S. W. Kycia, D. V. Soldatov and K. E. Preuss, Chem. Commun., 2017, 53, 3964
    DOI: 10.1039/C7CC00907K

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