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N-Heterocyclic carbene copper-catalyzed direct alkylation of terminal alkynes with non-activated alkyl triflates

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Abstract

(NHC)-Cu-catalyzed C(sp)–C(sp3) bond formation has been successfully achieved under mild conditions. Nonactivated alkyl triflates, which could be easily derived from alcohols, were utilized as C–O electrophiles. Mechanistic studies suggested that copper acetylide was the active species. Scale-up reactions further demonstrated the practicality and efficiency of the developed strategy.

Graphical abstract: N-Heterocyclic carbene copper-catalyzed direct alkylation of terminal alkynes with non-activated alkyl triflates

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Publication details

The article was received on 03 Feb 2017, accepted on 04 Mar 2017, published on 08 Mar 2017 and first published online on 08 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00891K
Citation: Chem. Commun., 2017, Advance Article
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    N-Heterocyclic carbene copper-catalyzed direct alkylation of terminal alkynes with non-activated alkyl triflates

    L. Jin, W. Hao, J. Xu, N. Sun, B. Hu, Z. Shen, W. Mo and X. Hu, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC00891K

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