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Issue 27, 2017
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A one-pot route to thioamides discovered by gas-phase studies: palladium-mediated CO2 extrusion followed by insertion of isothiocyanates

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Abstract

A new palladium mediated “one pot” synthesis of thioamides from aromatic carboxylic acids (ArCO2H + RNCS → ArC(S)NHR + CO2) was discovered by gas-phase experiments and theoretical studies. Palladium-mediated decarboxylation of aromatic carboxylic acids followed by addition of substituted isothiocyanates leads to the corresponding thioamide derivatives.

Graphical abstract: A one-pot route to thioamides discovered by gas-phase studies: palladium-mediated CO2 extrusion followed by insertion of isothiocyanates

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Publication details

The article was received on 02 Feb 2017, accepted on 10 Mar 2017, published on 10 Mar 2017 and first published online on 10 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00865A
Citation: Chem. Commun., 2017,53, 3854-3857
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    A one-pot route to thioamides discovered by gas-phase studies: palladium-mediated CO2 extrusion followed by insertion of isothiocyanates

    A. Noor, J. Li, G. N. Khairallah, Z. Li, H. Ghari, A. J. Canty, A. Ariafard, P. S. Donnelly and R. A. J. O'Hair, Chem. Commun., 2017, 53, 3854
    DOI: 10.1039/C7CC00865A

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