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Oligonucleotide promoted peptide bond formation using a tRNA mimicking approach

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Abstract

TransferRNA's role in protein translation is the prime example of an Informational Leaving Group (ILG). A simplified model produced oligophenylalanine with a modified uracil as an ILG in the presence of specific oligonucleotides. Our preliminary studies contribute to the importance of hybrid species in bridging the gap between peptides and nucleic acids.

Graphical abstract: Oligonucleotide promoted peptide bond formation using a tRNA mimicking approach

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Publication details

The article was received on 31 Jan 2017, accepted on 11 Apr 2017 and first published on 12 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC00831G
Citation: Chem. Commun., 2017, Advance Article
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    Oligonucleotide promoted peptide bond formation using a tRNA mimicking approach

    H.-P. Mattelaer, C.-A. Mattelaer, N. Papastavrou, W. Dehaen and P. Herdewijn, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC00831G

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