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Multiplexed gene silencing in living cells and in vivo using a DNAzymes–CoOOH nanocomposite

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Abstract

We demonstrate a novel DNAzymes-based nanocomposite that can simultaneously silence three types of genes in living cells and in vivo. The synergetic strategy for silencing three different genes can significantly enhance the knockdown efficacy and effectively inhibit the cancer cells’ progression.

Graphical abstract: Multiplexed gene silencing in living cells and in vivo using a DNAzymes–CoOOH nanocomposite

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Publication details

The article was received on 31 Jan 2017, accepted on 03 Apr 2017 and first published on 03 Apr 2017


Article type: Communication
DOI: 10.1039/C7CC00822H
Citation: Chem. Commun., 2017, Advance Article
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    Multiplexed gene silencing in living cells and in vivo using a DNAzymes–CoOOH nanocomposite

    N. Li, Y. Li, X. Gao, Z. Yu, W. Pan and B. Tang, Chem. Commun., 2017, Advance Article , DOI: 10.1039/C7CC00822H

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