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Issue 25, 2017
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Structural insights into the EthR–DNA interaction using native mass spectrometry

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Abstract

EthR is a transcriptional repressor that increases Mycobacterium tuberculosis resistance to ethionamide. In this study, the EthR–DNA interaction has been investigated by native electrospray-ionization mass spectrometry for the first time. The results show that up to six subunits of EthR are able to bind to its operator.

Graphical abstract: Structural insights into the EthR–DNA interaction using native mass spectrometry

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Publication details

The article was received on 30 Jan 2017, accepted on 07 Mar 2017 and first published on 07 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00804J
Citation: Chem. Commun., 2017,53, 3527-3530
  • Open access: Creative Commons BY license
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    Structural insights into the EthR–DNA interaction using native mass spectrometry

    D. Shiu-Hin Chan, W. Seetoh, B. N. McConnell, D. Matak-Vinković, S. E. Thomas, V. Mendes, M. Blaszczyk, A. G. Coyne, T. L. Blundell and C. Abell, Chem. Commun., 2017, 53, 3527
    DOI: 10.1039/C7CC00804J

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