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Issue 18, 2017
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X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore

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Abstract

The X-ray crystallographic structure of a truncated teixobactin analogue reveals hydrogen-bonding and hydrophobic interactions and a cavity that binds a chloride anion. Minimum inhibitory concentration (MIC) assays against Gram-positive bacteria correlate the observed structure with antibiotic activity.

Graphical abstract: X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore

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Publication details

The article was received on 30 Jan 2017, accepted on 10 Feb 2017 and first published on 13 Feb 2017


Article type: Communication
DOI: 10.1039/C7CC00783C
Citation: Chem. Commun., 2017,53, 2772-2775
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    X-ray crystallographic structure of a teixobactin analogue reveals key interactions of the teixobactin pharmacophore

    H. Yang, D. R. Du Bois, J. W. Ziller and J. S. Nowick, Chem. Commun., 2017, 53, 2772
    DOI: 10.1039/C7CC00783C

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