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Issue 27, 2017
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Azomethine-isocyanide [3+2] cycloaddition to imidazoles promoted by silver and DBU

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Abstract

A new silver-promoted [3+2] cycloaddition of azomethine ylides with isocyanides has been described. The methodology provides an efficient and modular approach to 1,2,4-trisubstituted imidazoles of vital bioactive molecules and atypical antipsychotics analogues.

Graphical abstract: Azomethine-isocyanide [3+2] cycloaddition to imidazoles promoted by silver and DBU

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Publication details

The article was received on 28 Jan 2017, accepted on 09 Mar 2017 and first published on 13 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00772H
Citation: Chem. Commun., 2017,53, 3858-3861
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    Azomethine-isocyanide [3+2] cycloaddition to imidazoles promoted by silver and DBU

    X. Huang, X. Cong, P. Mi and X. Bi, Chem. Commun., 2017, 53, 3858
    DOI: 10.1039/C7CC00772H

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