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Issue 26, 2017
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A two-photon fluorescent probe for real-time monitoring of autophagy by ultrasensitive detection of the change in lysosomal polarity

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Abstract

The first two-photon probe, Lyso-OC, was proposed for use in monitoring cell autophagy by detection of the change in the lysosomal polarity during the membrane fusion process of autophagy. The Lyso-OC probe exhibited desirable optical properties and a detection signal that was selective to the polarity change. More importantly, Lyso-OC displayed real-time monitoring of autophagy in living cells.

Graphical abstract: A two-photon fluorescent probe for real-time monitoring of autophagy by ultrasensitive detection of the change in lysosomal polarity

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Publication details

The article was received on 27 Jan 2017, accepted on 17 Feb 2017 and first published on 17 Feb 2017


Article type: Communication
DOI: 10.1039/C7CC00752C
Citation: Chem. Commun., 2017,53, 3645-3648
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    A two-photon fluorescent probe for real-time monitoring of autophagy by ultrasensitive detection of the change in lysosomal polarity

    J. Jiang, X. Tian, C. Xu, S. Wang, Y. Feng, M. Chen, H. Yu, M. Zhu and X. Meng, Chem. Commun., 2017, 53, 3645
    DOI: 10.1039/C7CC00752C

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