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Ribosome-Inactivating Protein Small Molecule Conjugates can Selectively Inhibit Target-Specific Tumor Cell Growth

Abstract

Cell-targeting conjugates of Saporin 6, a ribosome inactivating protein (RIP), were prepared using the Saporin Ala 157 Cys mutant, a small molecule inhibitor of integrin αvβ3, and a potent cytotoxin, auristatin F (AF). The conjugates selectively and potently inhibited proliferation of tumor cells expressing the target integrins. We anticipate that the small molecule-RIP bioconjugate approach can be broadly applied using other small molecule drugs.

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Publication details

The article was received on 27 Jan 2017, accepted on 16 Mar 2017, published on 17 Mar 2017 and first published online on 17 Mar 2017


Article type: Communication
DOI: 10.1039/C7CC00745K
Citation: Chem. Commun., 2017, Accepted Manuscript
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    Ribosome-Inactivating Protein Small Molecule Conjugates can Selectively Inhibit Target-Specific Tumor Cell Growth

    S. C. Sinha, S. Roy, J. Axup, J. S. Forsyth, R. K. Goswami, B. M. Hutchins, K. M. Bajuri, S. A. Kazane, V. V. Smider and B. H. Felding, Chem. Commun., 2017, Accepted Manuscript , DOI: 10.1039/C7CC00745K

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